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  • Oral Solid Dosage Form

    Prescriptions for successful solutions

    浙江11选5 www.pfjf.net While an apple a day keeps the doctor away (and the teacher happy) there comes a time, in almost everyone's life, when medication - in tablet form - is needed.  Our knowledge of the structure function of polymers, combined with our extensive product line can help you bind, coat, dissolve, and effectively deliver complex drug molecules where and when they're needed - making medication easier to swallow.  And, easy to swallow medication often yields better patient compliance,  which, in turn, yields better outcomes for everyone - a winning scenario. From concept to commericialization, working with Ashland makes medicine easy to swallow.

    Ashland is unsurpassed in its ability to develop solutions for effective and efficient solutions to deliver today's complex drug molecules where and when they are needed.  Our centers of excellence and manufacturing sites operate in accordance with cGMP standards. Our various chemistries and technologies are supported by a global team of research and development scientists. Ashland stands ready collaborate with you on new solutions to help take you from concept to commercialization.  Our solutions include:

    • Increasing the solubility of active pharmaceutical ingredients with low or no solubility
    • Designing modified-release products to meet targeted release profiles
    • Reducing tablet size while maintaining active pharmaceutical ingredient load
    • Improving disintegration time of orally disintegrating tablets
    • Understanding implications of continuous manufacturing technology for oral dosage production

    Ongoing research provides a foundation for advanced technical solutions to address these and future formulation and manufacturing challenges. Ashland provides formulators with industry-changing technologies and unique opportunities for research and development collaboration.

     

    read more >

    Aqualon? ethylcellulose (EC) is a cellulose ether distinguished by its versatility.

    Aqualon? ethylcellulose

    Our line of fully formulated, easily dispersed and ready-to-use Aquarius? film coating systems have a range of functions to suit almost any core. With our wide selection of film coating choices, we can provide an optimal coating for your unique formulation. The regulatory compliance information for all Ashland products varies by product family and grade. For specific data about the grade you are interested in please refer to our Excipient Informa...

    Aquarius? film coating systems

    AquaSolve? HPMCAS for pharmaceutical applications is a cellulosic polymer with four substituents randomly substituted on the available hydroxyl groups with the following mass content: methoxyl, 12–18 wt%; hydroxypropoxy, 4–23 wt%; acetyl, 2–16 wt% and succinoyl, 4–28 wt%. It is white to off-white in color and has a faint acetic acid-like odor and a barely detectable taste.  AquaSolve HPMCAS is available in several grades for pharmaceutical a...

    AquaSolve? hypromellose acetate succinate

    Benecel? methylcellulose and hypromellose (hydroxypropyl-methylcellulose or HPMC) are versatile excipients with a variety of applications. High-viscosity grades are widely used in hydrophilic matrix controlled-release systems. Low-viscosity grades are used for rheology control and as tablet binders. Benecel Grades Available -->

    Benecel? methylcellulose and hypromellose

    Blanose™ sodium carboxymethylcellulose (CMC) is made by reacting sodium monochloroacetate with alkalicellulose under rigidly controlled conditions. The resultant anionic polymer is purified and dried.  Purified CMC for personal care and cosmetic applications is typically sold at 99.5 percent minimum purity. In addition to thickening aqueous systems, CMC is used in personal care products for water binding, syneresis control and its abil...

    Blanose? sodium carboxymethylcellulose

    The molecular structure of cyclodextrins creates a bucket-like cavity that can complex with molecules or functional groups on molecules to improve solubility of poorly soluble compounds. The same mechanism makes these excipients capable of masking unpleasant taste/odor and stabilizing drugs that are prone to degradation. The number of glucose units in the ring determines the internal diameter of the cavity and its volume, as the height of the cyc...

    CAVAMAX? native cyclodextrins

    Klucel™ hydroxypropylcellulose (HPC) is a nonionic water-soluble cellulose ether with a remarkable combination of properties. It combines organic solvent solubility, thermoplasticity and surface activity with the aqueous thickening and stabilizing properties characteristic of other water-soluble cellulose polymers available from Ashland. Klucel HPC films are flexible without plasticizers and non-tacky at high humidity.

    Klucel? hydroxypropylcellulose

    Natrosol™ hydroxyethylcellulose (HEC), a nonionic, water-soluble polymer, is a white, free-flowing granular powder. It is made by reacting ethylene oxide with alkali-cellulose under rigidly controlled conditions. Purified HEC for personal care and cosmetic applications is typically sold at 95.0 percent minimum purity (dry basis).  Solutions of Natrosol HEC are pseudoplastic or shear-thinning. As a result, personal care products formula...

    Natrosol? hydroxyethylcellulose

    Aqualon™ sodium carboxymethylcellulose (CMC) is made by reacting sodium monochloroacetate with alkalicellulose under rigidly controlled conditions. The resultant anionic polymer is purified and dried. Purified CMC for personal care and cosmetic applications is typically sold at 99.5 percent minimum purity. In addition to thickening aqueous systems, CMC is used in personal care products for water binding, syneresis control and its ability to...

    Aqualon? sodium carboxymethylcellulose

    Ashland offers a comprehensive range of Plasdone povidones (PVP). Plasdone povidones are a family of water-soluble polymers based on N-vinylpyrrolidone that combine a unique set of properties for application in a wide variety of dosage forms. Plasdone povidones are commonly used as binders for the development of tablet formulations, whether manufactured by wet granulation, dry granulation or direct compression. Plasdone K polymers are used in sol...

    Plasdone? povidone

    Plasdone™ S-630 copovidone is a tablet binder, matrix polymer for solid-dispersion formulations and film former for topical applications. It is commonly used to enhance the solubility of active pharmaceutical ingredients and increase bioavailability of poorly soluble drugs through the formation of melt-extruded or spray-dried solid dispersions.

    Plasdone? S-630 copovidone

    Polyplasdone™ crospovidone superdisintegrants are synthetic, insoluble, but rapidly swellable, crosslinked homopolymers of N-vinyl-2-pyrrolidone. Crospovidone provides rapid disintegration and dissolution to oral solid dosage forms. Polyplasdone crospovidone particles are granular and porous compared with other superdisintegrants. The high surface area combined with unique chemistry results in high interfacial activity that enhances the dis...

    Polyplasdone? crospovidone

    Pharmasolve™ N-methyl-2-pyrrolidone (NMP) is a water-miscible polar aprotic solvent with high interfacial activity. It is used as a drug solubilizer and penetration enhancer in human topical dosage forms, and for the same purposes in parenteral and topical veterinary products. The regulatory compliance information for all Ashland products varies by product family and grade. For specific data about the grade you are interested in please refe...

    Pharmasolve? N-methyl-2-pyrrolidone

    The molecular structure of cyclodextrins creates a bucket-like cavity that can function to complex with molecules or functional groups on molecules. The substitution of hydroxyl groups on native cyclodextrins to make hydroxypropyl-?- or hydroxypropyl-γ-cyclodextrins (HPBCD or HBGCD) significantly enhances their solubility and makes them more suitable for drug solubilization. This mechanism makes the Cavitron and CAVASOL HPBCDs and HPGCDs capable ...

    Cavitron* cyclodextrin and CAVASOL* cyclodextrin

    Aquarius Preferred film coating systems disperse easily in water. These film coatings are applicable to both pharmaceutical and nutraceutical solid dosage forms. Ashland formulators have access to an unrivaled range of cellulosic and other polymeric excipients, enabling Aquarius film coating systems to be tailored to meet exacting requirements. To maximize the efficiency of the coating application process, high-solids loadings are desirable. By r...

    Aquarius? preferred film coating systems

    The Aquarius Control film coating systems consist of two types of coatings. Aquarius Control ENA film coating systems are delayed-release (enteric) coatings that are designed to protect active pharmaceutical ingredients (APIs) that degrade in gastric fluid, or to prevent the release of APIs that may irritate the gastric mucosa. Aquarius Control SRX film coating systems are sustained-release coatings for APIs that are most effective when released ...

    Aquarius? Control film coating systems

    Aquarius Prime film coating systems disperse easily in water and are applied to immediate-release dosage forms. Film coatings for immediate-release tablet-coating applications are typically comprised of a polymer, a plasticizer and optional pigment/opacifier. Aquarius Prime film coating systems are available in clear and white formulations off the shelf. Aquarius Prime film coating systems can be matched to customers’ existing HPMC fil...

    Aquarius? Prime film coating systems

    Aquarius™ Protect is a premium multi-functional barrier coating system to effectively reduce moisture uptake and mask against offensive taste and odor. For easier usability, Aquarius™ Protect is a fully formulated, ready-mixed coating that disperses quickly in water or solvent and is available in clear, white and color matched versions. Aquarius™ Protect delivers superior barrier properties and efficient flexible processing, wit...

    Aquarius? Protect film coating systems

    who helps you get to the finish line faster?__we do.introducing aquarius? genesis film coating systemAshland has a new, high-solids film-coating system for immediate-release applications. The Aquarius Genesis film coating is designed for application at up to 35% solids while producing films with outstanding strength, adhesion and smoothness. The pharmaceutical industry is moving from traditional batch manufacturing to continuous manufacturin...

    Aquarius? Genesis film coating systems

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  • 第九届安徽“省直机关读书月”游园活动举行 2019-04-18
  • “首届化工行业舆论风险管理高峰论坛”在京举行 2019-04-18
  • 戴利民的专栏作者中国国家地理网 2019-04-16
  • [网连中国]赛龙舟 包粽子 办诗会……全国各地品民俗迎端午 2019-04-11
  • 汇聚人才 贡献智慧 2019-04-11
  • 中国核电逆袭之路:从连钢筋水泥都需进口到走向世界 2019-04-07
  • 华浩科技:向世界推广具有中国自主知识产权的先进技术 2019-04-06
  • 看完《前任3》 你该做什么? 2019-04-06
  • 奥迪汽车排放造假事件再度发酵 董事长在德国被捕 2019-04-05
  • 莆田市:建立“网上大调解中心”经验做法 2019-04-05
  • 第五届西安(浐灞)金融高峰论坛举行 2019-04-03
  • 俞正声:贯彻以人民为中心的发展思想 2019-04-03
  • 空腹吃荔枝致孩子死亡?西安专家教你咋吃荔枝最科学 2019-03-30
  • 非遗展里的“甜蜜技艺” 2019-03-30
  • 合肥经开区拆除一处违规驾校训练场地 2019-03-19